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1. (WO2017189663) ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/189663    International Application No.:    PCT/US2017/029536
Publication Date: 02.11.2017 International Filing Date: 26.04.2017
IPC:
A61K 31/454 (2006.01), A61K 31/55 (2006.01), C07D 413/14 (2006.01)
Applicants: ENANTA PHARMACEUTICALS, INC. [US/US]; 500 Arsenal Street Watertown, MA 02472 (US)
Inventors: OR, Yat, Sun; (US).
WANG, Bin; (US).
XING, Xuechao; (US).
SHEN, Ruichao; (US).
GRANGER, Brett; (US).
MA, Jun; (US).
HE, Jing; (US).
HE, Yong; (US).
LONG, Jiang; (US).
WANG, Guoqiang; (US)
Agent: HARLAN, Edgar, W.; (US).
ELMORE, Carolyn, S.; (US)
Priority Data:
62/327,914 26.04.2016 US
Title (EN) ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
(FR) DÉRIVÉS D'ISOXAZOLE UTILISÉS COMME AGONISTES DE FXR ET LEURS MÉTHODES D'UTILISATION
Abstract: front page image
(EN)The present invention provides compounds of Formula (I), pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated as FXR modulators. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.
(FR)La présente invention concerne des composés de formule (I), des compositions pharmaceutiques comprenant ces composés et des méthodes d'utilisation de ces composés pour traiter ou prévenir une maladie ou un trouble médié par des modulateurs de FXR. Spécifiquement, la présente invention concerne des dérivés d'isoxazole utiles en tant qu'agonistes de FXR, et leurs méthodes de préparation et d'utilisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)