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1. (WO2017189652) ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF

Pub. No.:    WO/2017/189652    International Application No.:    PCT/US2017/029520
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Thu Apr 27 01:59:59 CEST 2017
IPC: A61K 31/454
A61K 31/55
C07D 413/14
Applicants: ENANTA PHARMACEUTICALS, INC.
Inventors: OR, Yat Sun
GRANGER, Brett
SHEN, Ruichao
XING, Xuechao
WANG, Bin
MA, Jun
HE, Jing
LONG, Jiang
HE, Yong
WANG, Guoqiang
Title: ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
Abstract:
The present invention provides compounds of Formula I: pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated as FXR modulators. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.