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1. (WO2017189586) BENZOYLGLYCINE DERIVATIVES AND METHODS OF MAKING AND USING SAME
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Pub. No.: WO/2017/189586 International Application No.: PCT/US2017/029429
Publication Date: 02.11.2017 International Filing Date: 25.04.2017
IPC:
A61K 31/165 (2006.01) ,C07C 237/34 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
28
having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
34
having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
Applicants:
DUKE UNIVERSITY [US/US]; 2812 Erwin Road Suite 306 Durham, NC 27705, US
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 109 Church Street Chapel Hill, North Carolina 27516, US
Inventors:
ZHOU, Pei; US
TOONE, Eric, J.; US
NICHOLAS, Robert, A.; US
GOPALASWAMY, Ramesh; US
LIANG, Xiaofei; US
NAVAS III, Frank; US
Agent:
LIBBY, Jelena, Janjic; US
Priority Data:
62/327,06125.04.2016US
Title (EN) BENZOYLGLYCINE DERIVATIVES AND METHODS OF MAKING AND USING SAME
(FR) DÉRIVÉS DE BENZOYLGLYCINE ET PROCÉDÉS DE PRODUCTION ET D'UTILISATION DE CES DÉRIVÉS
Abstract:
(EN) Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1,R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.
(FR) La présente invention concerne des composés des formules (I) et (II), et des sels pharmaceutiquement acceptables de ceux-ci, dans lesquelles les variables R1, R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n et m sont telles que définies dans la description. Ces composés sont utiles pour traiter les infections provoquées par des bactéries à Gram négatif. La présente invention concerne également des procédés de préparation desdits composés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)