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1. (WO2017189572) CRYSTALLINE POLYMORPHS OF OMBITASVIR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/189572    International Application No.:    PCT/US2017/029410
Publication Date: 02.11.2017 International Filing Date: 25.04.2017
IPC:
C07D 403/14 (2006.01), A61K 31/4025 (2006.01), A61P 31/14 (2006.01)
Applicants: ABBVIE INC. [US/US]; 1 North Waukegan Road North Chicago, Illinois 60064 (US)
Inventors: BRACKEMEYER, Paul J.; (US).
GARRETT, Colleen C.; (US).
NORDSTROEM, Lars Fredrik; (US).
SHEIKH, Ahmad Y.; (US).
ZHANG, Geoff G.; (US).
ZHU, Donghua; (US)
Agent: SRIVASTAVA, Sonali S.; (US).
AHMED, Aamer; (US).
BAUDE, Eric J.; (US).
CHEN, Portia; (US).
CORBIN, Johanna; (US).
GESICKI, Glen J.; (US).
JOHANNES, Laura; (US).
KAMPS, Matthew M.; (US).
SUN, Changxia; (US).
WARD, Michael J.; (US).
ZHANG, Xu; (US)
Priority Data:
62/328,972 28.04.2016 US
Title (EN) CRYSTALLINE POLYMORPHS OF OMBITASVIR
(FR) POLYMORPHES CRISTALLINS D'OMBITASVIR
Abstract: front page image
(EN)The present invention features crystalline polymorphs of dimethyl (2S, 2'S)-1,1, -((2S,2'S)-2, 2, -(4, 4, -((2S,5S)-1- (4-tert- butylphenyl) pyrrolidine-2,5-diyl) bis (4, l-phenylene)) bis (azanediyl) bis (oxomethylene) bis (pyrrolidine-2,l-diyl)) bis (3-methyl-l- oxobutane-2,1-diyl) dicarbamate i.e. ombitasvir, compound (I), which is a potent HCV NS5A inhibitor. In one embodiment, a crystalline form of Compound (I) has characteristic peaks in the PXRD pattern as shown in one of Figures 1-11.
(FR)La présente invention concerne des polymorphes cristallins de (2S,2'S)-1,1,-((2S,2'S)-2,2-(4,4-((2S,5S)-1-(4-tert-butylphényl)pyrrolidine-2,5-diyle)bis(4,1-phénylène))bis(azanediyl)bis(oxométhylène)bis(pyrrolidine-2,1-diyl))bis(3-méthyl-1-oxobutane-2,1-diyl)dicarbamate de diméthyle, c'est-à-dire l'ombitasvir, composé I, qui est un inhibiteur puissant de la protéine NS5A du VHC. Dans un mode de réalisation, une forme cristalline du composé I présente des pics caractéristiques dans le motif PXRD tels qu'illustrés dans une des figures 1-11.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)