WO2017189433 COMPOSITIONS COMPRISING COFORMULATION OF ANTI-PD-L1 AND ANTI-CTLA-4 ANTIBODIES

1. (WO2017189433) COMPOSITIONS COMPRISING COFORMULATION OF ANTI-PD-L1 AND ANTI-CTLA-4 ANTIBODIES

National Phase

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Latest bibliographic data on file with the International Bureau ⇨ Submit observation

Pub. No.:	WO/2017/189433	International Application No.:	PCT/US2017/029143
Publication Date:	02.11.2017	International Filing Date:	24.04.2017

IPC:

A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,C07K 16/28 (2006.01)

Applicants:

MEDIMMUNE, LLC[US/US]; One Medimmune Way Gaithersburg, MD 20878, US

Inventors:

DU, Jiali; US
SHAH, Ambarish; US

Agent:

MENSAH, Kwame, N.; US
BRASLOW, Kimberly; US
ALBAN, Patrick; US
DISE, Rebecca, S.; US
CARROLL, Sahnnon; US

Priority Data:

62/327,214

25.04.2016

Title

(EN) COMPOSITIONS COMPRISING COFORMULATION OF ANTI-PD-L1 AND ANTI-CTLA-4 ANTIBODIES
(FR) COMPOSITIONS COMPRENANT UNE CO-FORMULATION D'ANTICORPS ANTI-PD-L1 ET ANTI-CTLA-4

Abstract:

(EN) Provided herein are compositions comprising coformulation of anti-PD-Ll and anti-CTLA-4 antibodies, or antigen-binding fragments thereof, and methods of making and using such compositions. In various aspects, stable coformulations of the anti-PD-Ll antibody durvalumab (MEDI4736) and the anti-CTLA-4 antibody tremelimumab are provided.
(FR) La présente invention concerne des compositions comprenant une co-formulation d'anticorps anti-PD-L1 et anti-CTLA-4, ou des fragments de liaison d’antigène de ceux-ci, et des procédés de fabrication et d'utilisation de telles compositions. Dans différents aspects, l'invention concerne des co-formulations stables de l'anticorps anti-PD-L1 durvalumab (MEDI4736) et de l'anticorps anti-CTLA-4 trémélimumab.

Designated States:

AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)

Publication Language:

English (EN)

Filing Language:

English (EN)

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