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1. (WO2017189433) COMPOSITIONS COMPRISING COFORMULATION OF ANTI-PD-L1 AND ANTI-CTLA-4 ANTIBODIES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/189433 International Application No.: PCT/US2017/029143
Publication Date: 02.11.2017 International Filing Date: 24.04.2017
IPC:
A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,C07K 16/28 (2006.01)
Applicants: MEDIMMUNE, LLC[US/US]; One Medimmune Way Gaithersburg, MD 20878, US
Inventors: DU, Jiali; US
SHAH, Ambarish; US
Agent: MENSAH, Kwame, N.; US
BRASLOW, Kimberly; US
ALBAN, Patrick; US
DISE, Rebecca, S.; US
CARROLL, Sahnnon; US
Priority Data:
62/327,21425.04.2016US
Title (EN) COMPOSITIONS COMPRISING COFORMULATION OF ANTI-PD-L1 AND ANTI-CTLA-4 ANTIBODIES
(FR) COMPOSITIONS COMPRENANT UNE CO-FORMULATION D'ANTICORPS ANTI-PD-L1 ET ANTI-CTLA-4
Abstract: front page image
(EN) Provided herein are compositions comprising coformulation of anti-PD-Ll and anti-CTLA-4 antibodies, or antigen-binding fragments thereof, and methods of making and using such compositions. In various aspects, stable coformulations of the anti-PD-Ll antibody durvalumab (MEDI4736) and the anti-CTLA-4 antibody tremelimumab are provided.
(FR) La présente invention concerne des compositions comprenant une co-formulation d'anticorps anti-PD-L1 et anti-CTLA-4, ou des fragments de liaison d’antigène de ceux-ci, et des procédés de fabrication et d'utilisation de telles compositions. Dans différents aspects, l'invention concerne des co-formulations stables de l'anticorps anti-PD-L1 durvalumab (MEDI4736) et de l'anticorps anti-CTLA-4 trémélimumab.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)