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1. (WO2017189339) PROCESS FOR THE PREPARATION OF N-[(5-PYRIMIDINYL)METHYL]-2-PYRIDINAMINES

Pub. No.:    WO/2017/189339    International Application No.:    PCT/US2017/028703
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Sat Apr 22 01:59:59 CEST 2017
IPC: C07D 401/12
C07D 471/04
Applicants: E I DU PONT DE NEMOURS AND COMPANY
Inventors: DUMAS, Donald J.
TRAN, Loc Thanh
Title: PROCESS FOR THE PREPARATION OF N-[(5-PYRIMIDINYL)METHYL]-2-PYRIDINAMINES
Abstract:
Disclosed is a method for preparing a compound of Formula (1) wherein R1 is H or C1-C3 alkyl, and the use of a compound of Formula (1) in a method for preparing mesoionic compounds, comprising: (A) contacting a compound of Formula (2) with 2-aminopyridine (3) in the presence of an inert solvent, optionally in the presence of an acid catalyst, to form a compound of Formula (4) (Β) contacting the compound of Formula (4) with an alcohol R2OH to form a compound of Formula (5) in the presence of an inert solvent wherein R2 is C1-C4 alkyl; and (C) contacting the compound of Formula (5) with a borohydride reducing agent in the presence of an inert solvent to form a reaction mixture comprising the compound of Formula (1).