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1. (WO2017188435) METHOD FOR MANUFACTURING BONE-REGENERATION MATERIAL COMPRISING BIODEGRADABLE FIBERS BY USING ELECTROSPINNING METHOD
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Pub. No.: WO/2017/188435 International Application No.: PCT/JP2017/016931
Publication Date: 02.11.2017 International Filing Date: 28.04.2017
IPC:
A61L 27/18 (2006.01) ,A61L 27/12 (2006.01) ,A61L 27/46 (2006.01) ,A61L 27/58 (2006.01) ,D01D 5/08 (2006.01) ,D01F 1/02 (2006.01) ,D01F 6/62 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
18
obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
02
Inorganic materials
12
Phosphorus-containing materials, e.g. apatite
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
40
Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
44
having a macromolecular matrix
46
with phosphorus-containing inorganic fillers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
58
Materials at least partially resorbable by the body
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
D
MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES, OR RIBBONS
5
Formation of filaments, threads, or the like
08
Melt-spinning methods
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
F
CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES, OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
1
General methods for the manufacture of artificial filaments or the like
02
Addition of substances to the spinning solution or to the melt
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
F
CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES, OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
6
Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
58
from homopolycondensation products
62
from polyesters
Applicants:
国立大学法人名古屋工業大学 NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY [JP/JP]; 愛知県名古屋市昭和区御器所町字木市29番 29, Aza Kiichi, Gokiso-cho, Showa-ku, Nagoya-shi Aichi 4660061, JP
ORTHOREBIRTH株式会社 ORTHOREBIRTH CO., LTD. [JP/JP]; 神奈川県横浜市都筑区茅ヶ崎東三丁目17番43号 3-17-43, Chigasaki Higashi, Tsuzuki-ku, Yokohama-shi Kanagawa 2240033, JP
Inventors:
春日 敏宏 KASUGA Toshihiro; JP
西川靖俊 NISHIKAWA Yasutoshi; JP
Agent:
二宮 克之 NINOMIYA Katsuyuki; JP
Priority Data:
2016-09111828.04.2016JP
Title (EN) METHOD FOR MANUFACTURING BONE-REGENERATION MATERIAL COMPRISING BIODEGRADABLE FIBERS BY USING ELECTROSPINNING METHOD
(FR) PROCÉDÉ DE FABRICATION DE MATÉRIAU DE RÉGÉNÉRATION OSSEUSE COMPRENANT DES FIBRES BIODÉGRADABLES AU MOYEN D'UN PROCÉDÉ D'ÉLECTROFILAGE
(JA) エレクトロスピニング法を用いて生分解性繊維からなる骨再生用材料を製造するための方法
Abstract:
(EN) There is a demand for a novel method for manufacturing, with commercial efficiency, a bone-regeneration material that contains calcium phosphate particles in a biodegradable fiber comprising PLGA by using electrospinning, and a novel bone-regeneration material manufactured using the method. According to the present invention, a PLGA resin is heated in a kneader so as to be softened until the viscosity of the resin becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is poured while the blade of the kneader is being rotated, and mixed with the softened PLGA resin. The mixture is kneaded by applying thermal and mechanical energy to the mixture through the continuous rotation of the blade of the kneader in the heated state, and aggregations of the calcium phosphate fine particles are disintegrated to prepare a composite in which the calcium phosphate fine particles are dispersed in the PLGA resin. The composite is dissolved by a solvent, and the PLGA resin is completely dissolved by the solvent through agitation for a prescribed period of time to prepare a spinning solution in which the calcium phosphate fine particles are dispersed without being aggregated in a solution having the PLGA resin dissolved therein. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.
(FR) Il existe une demande d’un nouveau procédé de fabrication, avec une efficacité commerciale, d’un matériau de régénération osseuse qui contient des particules de phosphate de calcium dans une fibre biodégradable comprenant du PLGA par électrofilage, et un nouveau matériau de régénération osseuse fabriqué au moyen du procédé. Selon la présente invention, une résine de PLGA est chauffée dans un malaxeur de façon à être ramollie jusqu'à ce que la viscosité de la résine devienne de 102 à 107 Pa.s. Une poudre de particules fines de phosphate de calcium est versée tandis que la pale du malaxeur est mise en rotation, et mélangée à la résine de PLGA ramollie. Le mélange est malaxé par application d'énergie thermique et mécanique au mélange par rotation continue de la pale du malaxeur dans l'état chauffé, et des agrégations des particules fines de phosphate de calcium sont désintégrées pour préparer un composite dans lequel les particules fines de phosphate de calcium sont dispersées dans la résine de PLGA. Le composite est dissous par un solvant, et la résine de PLGA est complètement dissoute par le solvant par agitation pendant une durée prescrite pour préparer une solution de filage dans laquelle les particules fines de phosphate de calcium sont dispersées sans être agrégées dans une solution dans laquelle la résine de PLGA est dissoute. L'électrofilage est effectué sur la solution de filage pour fabriquer des fibres biodégradables dans lesquelles les particules fines de phosphate de calcium sont dispersées de façon sensiblement uniforme.
(JA) PLGAからなる生分解性繊維にリン酸カルシウム粒子を含有させた骨再生用材料をエレクトロスピニングを用いて商業的効率性をもって製造するための新たな方法、およびその方法で製造された新たな骨再生用材料が求められている。 PLGA樹脂をニーダー中で加熱して、樹脂の粘度が102~107Pa・sになるまで軟化させ、リン酸カルシウム微粒子の粉体をニーダーの羽根を回転させながら投入することによって、粉体を軟化したPLGA樹脂と混合し、ニーダーの羽根を前記加熱状態で継続して回転させることによって前記混合物に対して熱的かつ機械的エネルギーをかけて混練し、リン酸カルシウム微粒子の凝集を解砕することによって、リン酸カルシウムの微粒子がPLGA樹脂中に分散した複合体を作製し、前記複合体を溶剤で溶かし、所定時間撹拌することによって、PLGA樹脂が溶剤によって完全に溶解され、かつリン酸カルシウム微粒子がPLGA樹脂が溶解された溶液中で凝集することなく分散した紡糸溶液を作製し、当該紡糸溶液を用いてエレクトロスピニングすることによって、リン酸カルシウム微粒子が生分解性繊維中に略均一に分散している生分解性繊維を製造する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)