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1. (WO2017188356) ANTIBODY-CONTAINING PREPARATION

Pub. No.:    WO/2017/188356    International Application No.:    PCT/JP2017/016658
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Fri Apr 28 01:59:59 CEST 2017
IPC: A61K 39/395
A61K 47/18
A61K 47/34
A61K 9/08
A61P 7/04
Applicants: CHUGAI SEIYAKU KABUSHIKI KAISHA
中外製薬株式会社
Inventors: SAEKI, Atsushi
佐伯 厚
NISHIZAWA, Shaw
西澤 翔
SASAKI, Hitoshi
佐々木 仁
IMAI, Chifumi
今井 千史
IGAWA, Tomoyuki
井川 智之
Title: ANTIBODY-CONTAINING PREPARATION
Abstract:
The present invention relates to a stable antibody-containing liquid preparation which rarely undergoes the formation of aggregates of Emicizumab (ACE910) that is a bispecific antibody having a function alternative to the function of FVIII. More specifically, the present invention relates to the aforementioned antibody-containing liquid preparation which contains 20 to 180 mg/mL of the aforementioned bispecific antibody, 10 to 40 mM of a histidine-aspartate buffer solution, 0.2 to 1 mg/mL of Poloxamer 188 and 100 to 300 mM of arginine and has a pH value of 4.5 to 6.5.