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1. (WO2017188311) ORALLY DISINTEGRATING TABLET EVALUATING METHOD, AND ORALLY DISINTEGRATING TABLET EVALUATING DEVICE

Pub. No.:    WO/2017/188311    International Application No.:    PCT/JP2017/016529
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Thu Apr 27 01:59:59 CEST 2017
IPC: G01N 5/00
A61K 9/20
G01N 33/15
Applicants: SAWAI PHARMACEUTICAL CO., LTD.
沢井製薬株式会社
Inventors: NAKATANI Masatoshi
中谷 匡利
SUGITA Masaru
杉田 優
IKEJI Nobuaki
池治 宣晃
NOZAWA Kenji
野沢 健児
Title: ORALLY DISINTEGRATING TABLET EVALUATING METHOD, AND ORALLY DISINTEGRATING TABLET EVALUATING DEVICE
Abstract:
Provided is an evaluating method capable of appropriately evaluating a degree of disintegration of an orally disintegrating tablet irrespective of the prescription system. Also provided is an evaluating device capable of appropriately evaluating a degree of disintegration of an orally disintegrating tablet irrespective of the prescription system. The method of evaluating an orally disintegrating tablet according to one mode of embodiment of the present invention includes: measuring the mass of the orally disintegrating tablet; placing the orally disintegrating tablet on a preparation placement surface of a test solution supply unit; measuring a water absorption time for a test solution to penetrate from one end of the orally disintegrating tablet in contact with the preparation placement surface to the other end of the orally disintegrating tablet; measuring the mass of the orally disintegrating tablet for which the time for the test solution to penetrate has been measured; and calculating a water absorption rate of the orally disintegrating tablet from the following formula (1); wherein the water absorption rate of the orally disintegrating tablet is evaluated relative to a water absorption rate of 0.004 g/sec. [Formula 1] Water absorption rate of orally disintegrating tablet = (mass of orally disintegrating tablet after measurement of time for test solution to be absorbed - mass of orally disintegrating tablet before measurement of time for test solution to be absorbed) / time for test solution to penetrate from one end to other end of orally disintegrating tablet (1)