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|1. (WO2017187656) ASSAY METHOD FOR ANTI-DRUG ANTIBODIES|
|Applicants:||JIMRO CO., LTD.
|Title:||ASSAY METHOD FOR ANTI-DRUG ANTIBODIES|
Provided is a method for more simply and accurately measuring ADAs that develop in a patient receiving drug-based, molecular-targeted therapy, or the like. This assay method for ADAs in an assay sample includes the following steps (1) to (4). (1) A step for preparing a specimen which includes an assay sample of ADAs; (2) a step for bringing the specimen prepared in step (1) into contact with a support on which complement C1q, an anti-C3d antibody, or an anti-C1q antibody has been immobilized; (3) a step for bringing a labeled or unlabeled antibody to the drug corresponding to the aforementioned ADAs into contact with the solid-phase support produced in step (2); and (4) a step for measuring the quantity of drug-ADA immune complexes bound to complement C1q, the anti-C3d antibody, or the anti-C1q antibody.