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1. (WO2017186942) ANTIMICROBIAL AGENTS AGAINST SALMONELLA BACTERIA

Pub. No.:    WO/2017/186942    International Application No.:    PCT/EP2017/060264
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Sat Apr 29 01:59:59 CEST 2017
IPC: C12N 9/50
C12N 9/36
C07K 14/46
Applicants: LYSANDO AG
Inventors: GRIESSL, Martin
BIEBL, Manfred
SCHIRMEIER, Eva
Title: ANTIMICROBIAL AGENTS AGAINST SALMONELLA BACTERIA
Abstract:
The present invention relates to the field of antimicrobial agents active against Salmonella bacteria. In particular, the present invention relates to polypeptides comprising a first and a second amino acid sequence, wherein the first amino acid sequence is an endolysin, and wherein the second amino acid sequence is an antimicrobial peptide, cationic peptide, hydrophobic peptide, amphipathic peptide or sushi peptide, and wherein the polypeptide comprises at least one sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4 and derivatives thereof. In addition, the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding host cells. Finally, the present invention relates to applications of the inventive polypeptides, nucleic acids, vectors, and/or host cells, in particular in the pharmaceutical field and in the field of food and feed.