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1. (WO2017186853) T CELL-BASED BI-SPECIFIC IMMUNOTHERAPEUTICS

Pub. No.:    WO/2017/186853    International Application No.:    PCT/EP2017/060061
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Fri Apr 28 01:59:59 CEST 2017
IPC: C12N 15/62
Applicants: BCRT HOLDING BV
ABTCO B.V.
Inventors: LINNEMANN, Carsten
DE BOER, Mark
SCHUMACHER, Antonius Nicolaas Maria
VAN TETERING, Geert
BRAEM, Steven
Title: T CELL-BASED BI-SPECIFIC IMMUNOTHERAPEUTICS
Abstract:
The present invention provides compositions and methods for immunotherapy in humans. The invention includes a bi-specific B cell receptor like complex expressed in T cells and comprising a bi-specific extracellular antigen recognition domain, a trans-membrane domain, a CD79αβ heterodimer, and a signaling region that controls T cell activation. The bi-specific extracellular antigen recognition domain and trans-membrane domain are from the same bi-specific human or humanized Ig-like molecule in the complex. The signaling region comprises a T cell signaling domain in combination with a co-stimulatory signaling domain. The signaling domain is fused to the CD79αβ heterodimer.