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1. (WO2017186102) A THERAPEUTIC INHIBITOR FOR EBV-ASSOCIATED TUMOR WITH TAILOR RESPONSIVE OPTICAL IMAGING
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Pub. No.: WO/2017/186102 International Application No.: PCT/CN2017/081903
Publication Date: 02.11.2017 International Filing Date: 25.04.2017
IPC:
A61K 39/245 (2006.01) ,G01N 33/533 (2006.01) ,A61P 31/22 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
245
Herpetoviridae, e.g. herpes simplex virus
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
531
Production of immunochemical test materials
532
Production of labelled immunochemicals
533
with fluorescent label
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
22
for herpes viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
HONG KONG BAPTIST UNIVERSITY [CN/CN]; Kowloon Tong Kowloon, Hong Kong, CN
Inventors:
WONG, Ka Leung; CN
MAK, Nai Ki; CN
JIANG, Lijun; CN
Agent:
BEIJING PAT SF INTELLECTUAL PROPERTY AGENCY CO. LTD; 1110-11, A, Floor 11, Chengjian Plaza, 18 Beitaipingzhuang Road, Haidian District Beijing 100088, CN
Priority Data:
15/495,97124.04.2017US
62/327,50426.04.2016US
62/406,92711.10.2016US
Title (EN) A THERAPEUTIC INHIBITOR FOR EBV-ASSOCIATED TUMOR WITH TAILOR RESPONSIVE OPTICAL IMAGING
(FR) INHIBITEUR THÉRAPEUTIQUE POUR UNE TUMEUR ASSOCIÉE AU EBV AVEC UNE IMAGERIE OPTIQUE SENSIBLE PERSONNALISÉE
Abstract:
(EN) It is provided a nucleus-permeable small-molecule inhibitor, L2P4 (where L2 is 4-(4-( Diethylamino)styryl)-N-carboxymethylpryidinium chloride and P4 is an amino acid sequence comprising CAhxYFMVFGGRrRK and they were coupled through amide bond) and synthesis thereof, which effectively targets the dimerization interface of EBNA1, a critical process for the growth of EBVs and the associated tumors. The method of treating and imaging EBV-associated cancers is also provided.
(FR) L'invention concerne un inhibiteur à petite molécule à perméabilité nucléaire, L2P 4 (où L2 représente le chlorure de 4-(4-(diéthylamino)styryl)-N-carboxyméthylpryridinium et P4 représente une séquence d'acides aminés comprenant CAhxYFMVFGGRrRK et ils ont été couplés par l'intermédiaire d'une liaison amide) et la synthèse de ce dernier, qui cible efficacement l'interface de dimérisation de EBNA1, un processus critique pour la croissance des EBV et des tumeurs associées. L'invention concerne également le procédé de traitement et d'imagerie de cancers associés au EBV.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)