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1. (WO2017186077) METHOD FOR PREPARING SUSTAINED RELEASE MICROPARTICLE

Pub. No.:    WO/2017/186077    International Application No.:    PCT/CN2017/081640
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Tue Apr 25 01:59:59 CEST 2017
IPC: A61K 9/16
A61K 47/34
A61K 38/26
A61K 38/17
A61K 38/35
A61K 38/31
A61K 38/11
A61K 38/08
A61K 38/09
A61K 38/20
Applicants: AC PHARMACEUTICALS CO., LTD.
广州帝奇医药技术有限公司
Inventors: LIU, Feng
刘锋
LAI, Shuting
赖树挺
ZHENG, Yang
郑阳
CAO, Fuchun
曹付春
LIAN, Yuanfa
连远发
Title: METHOD FOR PREPARING SUSTAINED RELEASE MICROPARTICLE
Abstract:
A method for preparing sustained release microparticles, comprising the following steps of: 1) preparing a solid dispersion of a water-soluble drug and a biodegradable and biocompatible water-insoluble polymer; 2) dissolving the prepared solid dispersion into an organic solvent to form an emulsion of the solid dispersion; 3) injecting the obtained emulsion of the solid dispersion into an aqueous solution containing a surfactant to form a uniform emulsion; 4) curing microparticles in the emulsion by means of solvent volatilization or solvent extraction, collecting the microparticles, washing and drying same to obtain the sustained release microparticles. The whole method for preparing the sustained release microparticles is carried out at a normal temperature or a low temperature, the prepared sustained release microparticles have a near-zero order sustained release effect, and the concentration of the drug remains stable during the sustained release period.