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|1. (WO2017186077) METHOD FOR PREPARING SUSTAINED RELEASE MICROPARTICLE|
|Applicants:||AC PHARMACEUTICALS CO., LTD.
|Title:||METHOD FOR PREPARING SUSTAINED RELEASE MICROPARTICLE|
A method for preparing sustained release microparticles, comprising the following steps of: 1) preparing a solid dispersion of a water-soluble drug and a biodegradable and biocompatible water-insoluble polymer; 2) dissolving the prepared solid dispersion into an organic solvent to form an emulsion of the solid dispersion; 3) injecting the obtained emulsion of the solid dispersion into an aqueous solution containing a surfactant to form a uniform emulsion; 4) curing microparticles in the emulsion by means of solvent volatilization or solvent extraction, collecting the microparticles, washing and drying same to obtain the sustained release microparticles. The whole method for preparing the sustained release microparticles is carried out at a normal temperature or a low temperature, the prepared sustained release microparticles have a near-zero order sustained release effect, and the concentration of the drug remains stable during the sustained release period.