Search International and National Patent Collections

1. (WO2017186074) METHOD FOR PREPARING SUSTAINED RELEASE MICROPARTICLES, PREPARED SUSTAINED RELEASE MICROPARTICLES AND APPLICATION THEREOF

Pub. No.:    WO/2017/186074    International Application No.:    PCT/CN2017/081637
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Tue Apr 25 01:59:59 CEST 2017
IPC: A61K 9/16
A61K 38/26
A61K 47/34
A61K 38/16
A61K 38/31
A61K 38/11
A61K 38/08
A61K 38/10
A61K 38/09
A61K 38/17
A61K 38/20
Applicants: AC PHARMACEUTICALS CO., LTD.
广州帝奇医药技术有限公司
Inventors: LIU, Feng
刘锋
LAI, Shuting
赖树挺
ZHENG, Yang
郑阳
CAO, Fuchun
曹付春
LIAN, Yuanfa
连远发
Title: METHOD FOR PREPARING SUSTAINED RELEASE MICROPARTICLES, PREPARED SUSTAINED RELEASE MICROPARTICLES AND APPLICATION THEREOF
Abstract:
A method for preparing sustained release microparticles, comprising the following steps: 1) preparing a solid dispersion of a water-soluble drug and a biodegradable and biocompatible water-insoluble polymer; 2) dissolving the prepared solid dispersion in an organic solvent to form a solid dispersion emulsion; 3) injecting the obtained solid dispersion emulsion into an oil solution with surfactants to form an uniform emulsion; and 4) curing microparticles in the emulsion by means of solvent evaporation or solvent extraction, and collecting, washing, and drying the microparticles to obtain the sustained release microparticles. Sustained release microparticles prepared by means of the method for preparing sustained release microparticles as well as application of the sustained release microparticles in an implantable sustained release pharmaceutical composition. The method for preparing sustained release microparticles is carried out at the normal temperature or a low temperature in full procedures. The prepared sustained release microparticles have an approximate zero-level sustained release effect, and the drug is stable in concentration in the sustained release period.