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|1. (WO2017186074) METHOD FOR PREPARING SUSTAINED RELEASE MICROPARTICLES, PREPARED SUSTAINED RELEASE MICROPARTICLES AND APPLICATION THEREOF|
|Applicants:||AC PHARMACEUTICALS CO., LTD.
|Title:||METHOD FOR PREPARING SUSTAINED RELEASE MICROPARTICLES, PREPARED SUSTAINED RELEASE MICROPARTICLES AND APPLICATION THEREOF|
A method for preparing sustained release microparticles, comprising the following steps: 1) preparing a solid dispersion of a water-soluble drug and a biodegradable and biocompatible water-insoluble polymer; 2) dissolving the prepared solid dispersion in an organic solvent to form a solid dispersion emulsion; 3) injecting the obtained solid dispersion emulsion into an oil solution with surfactants to form an uniform emulsion; and 4) curing microparticles in the emulsion by means of solvent evaporation or solvent extraction, and collecting, washing, and drying the microparticles to obtain the sustained release microparticles. Sustained release microparticles prepared by means of the method for preparing sustained release microparticles as well as application of the sustained release microparticles in an implantable sustained release pharmaceutical composition. The method for preparing sustained release microparticles is carried out at the normal temperature or a low temperature in full procedures. The prepared sustained release microparticles have an approximate zero-level sustained release effect, and the drug is stable in concentration in the sustained release period.