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1. (WO2017186056) SURFACE ENHANCED RAMAN SCATTERING TECHNIQUE BASED DETECTION CHIP, PREPARATION METHOD THEREFOR, KIT AND TUMOUR DETECTION METHOD
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Pub. No.:
WO/2017/186056
International Application No.:
PCT/CN2017/081420
Publication Date:
02.11.2017
International Filing Date:
21.04.2017
IPC:
G01N 21/65
(2006.01)
G
PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
62
Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63
optically excited
65
Raman scattering
Applicants:
INSTITUTE OF HIGH ENERGY PHYSICS , CHINESE ACADEMY OF SCIENCES
[CN/CN]; 19B YuquanLu, Shijingshan District Beijing 100049 (CN)
Inventors:
LI, Min
; (CN).
ZHU, Wenfeng
; (CN).
ZHAO, Yuliang
; (CN)
Agent:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD.
; 1802, 1803, 1805 Tower B, Grand Place, No. 5 Huizhong Road, Chaoyang District Beijing 100101 (CN)
Priority Data:
201610262077.5
25.04.2016
CN
Title
(EN)
SURFACE ENHANCED RAMAN SCATTERING TECHNIQUE BASED DETECTION CHIP, PREPARATION METHOD THEREFOR, KIT AND TUMOUR DETECTION METHOD
(FR)
PUCE DE DÉTECTION BASÉE SUR UNE TECHNIQUE DE DIFFUSION RAMAN EXALTÉE DE SURFACE, SON PROCÉDÉ DE PRÉPARATION, TROUSSE, ET PROCÉDÉ DE DÉTECTION DE TUMEUR
(ZH)
一种基于表面增强拉曼散射技术的检测芯片、制备方法、试剂盒以及肿瘤检测方法
Abstract:
(EN)
Provided is a surface enhanced Raman scattering technique based detection chip, comprising: a nano metal substrate, two or more signal molecules, and two or more detection objects for detecting tumour markers, wherein the signal molecules are uniformly distributed on the substrate, and the detection objects are respectively fixed onto different signal molecules. Also provided are a preparation method for a detection chip, and a kit containing same, and a tumour detection method. By fixing different Raman signal molecules to different micro zones, synchronous and quantitative detection of a plurality of tumour markers are realized by using a nano-stress sensing technique, having a tremendous application potential.
(FR)
L'invention concerne une puce de détection basée sur une technique de diffusion Raman exaltée de surface comprenant : un substrat métallique nanométrique, au moins deux molécules signal, et au moins deux objets de détection servant à détecter des marqueurs tumoraux, les molécules signal étant uniformément réparties sur le substrat, et les objets de détection étant respectivement fixés sur différentes molécules signal. L'invention concerne également un procédé de préparation d'une puce de détection, un kit contenant ladite puce et un procédé de détection de tumeur. En fixant différentes molécules de signal Raman à différentes micro-zones, une détection synchrone et quantitative d'une pluralité de marqueurs tumoraux est obtenue en utilisant une technique de détection de nano-contrainte, ce qui permet un nombre d'applications possibles considérable.
(ZH)
一种基于表面增强拉曼散射技术的检测芯片,包括:纳米金属基底,两种或两种以上的信号分子、以及两种或两种以上的用于检测肿瘤标志物的检测物,信号分子均匀分布于基底之上,检测物分别固定于不同的信号分子上。一种检测芯片的制备方法以及包含其的检测试剂盒,以及一种肿瘤检测方法。通过在不同微区固定不同拉曼信号分子,利用纳应力传感技术实现对多种肿瘤标志物的同时定量检测,具有巨大的应用潜力。
Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language:
Chinese (
ZH
)
Filing Language:
Chinese (
ZH
)