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1. (WO2017185900) CROCINS COMPOUNDS AND USES THEREOF
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Pub. No.: WO/2017/185900 International Application No.: PCT/CN2017/076911
Publication Date: 02.11.2017 International Filing Date: 16.03.2017
IPC:
C07H 13/04 (2006.01) ,C07H 13/06 (2006.01) ,C07H 1/08 (2006.01) ,A61K 31/7024 (2006.01) ,A61P 25/28 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13
Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02
by carboxylic acids
04
having the esterifying carboxyl radicals attached to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13
Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02
by carboxylic acids
04
having the esterifying carboxyl radicals attached to acyclic carbon atoms
06
Fatty acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1
Processes for the preparation of sugar derivatives
06
Separation; Purification
08
from natural products
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7024
Esters of saccharides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
暨南大学 JINAN UNIVERSITY [CN/CN]; 中国广东省广州 天河区黄埔大道西601号 No. 601, Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, CN
Inventors:
姚新生 YAO, Xinsheng; CN
于洋 YU, Yang; CN
张丹 ZHANG, Dan; CN
倪阳 NI, Yang; CN
鲍秀琦 BAO, Xiuqi; CN
李林 LI, Lin; CN
臧彩霞 ZANG, Caixia; CN
高昊 GAO, Hao; CN
郑远鹏 ZHENG, Yuanpeng; CN
Agent:
北京市金杜律师事务所 KING & WOOD MALLESONS; 中国北京市 朝阳区东三环中路1号环球金融中心办公楼东楼20层 20th Floor, East Tower, World Financial Centre, No. 1 Dongsanhuan Zhonglu, Chaoyang District, Beijing 100020, CN
Priority Data:
201610284974.629.04.2016CN
Title (EN) CROCINS COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS DE TYPE CROCINE ET UTILISATIONS CORRESPONDANTES
(ZH) 藏红花色素类化合物及其用途
Abstract:
(EN) Provided are a series of crocins compounds and related pharmacological application thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.
(FR) L'invention concerne une série de composés de type crocine et une application pharmacologique correspondante dans la prévention et le traitement de la maladie d'Alzheimer. La série de composés de type crocine est obtenue en ce qu'on prend une herbe chinoise, à savoir Gardenia jasminoides Ellis, en tant que matière première et on la sépare au moyen de divers procédés. Les composés qui jouent un rôle dans la prévention de lésions oxydatives provoquées par le peroxyde d'hydrogène (H2O2) et de lésions d'acides aminés excitateurs provoquées par l'acide L-glutamique sont éliminés par criblage par des expériences cellulaires in vitro. Les résultats montrent que les composés de type crocine présentent un bon effet dans la prévention de lésions cellulaires provoquées par H2O2 et l'acide L-glutamique. Les composés ont un bon effet dans la prévention et le traitement de la maladie d'Alzheimer en raison du fait qu'une augmentation significative du stress oxydatif et des acides aminés excitateurs est un facteur clé pour les lésions nerveuses dans la maladie d'Alzheimer et présentent une grande perspective de développement et d'application.
(ZH) 提供一系列藏红花色素类化合物及其在防治阿尔茨海默症方面的相关药理应用。以中药栀子为原料,通过多种分离方法得到一系列藏红花色素类化合物,以体外细胞实验筛选具有保护过氧化氢(H 2O 2)引起的氧化损伤和 L-谷氨酸所引起的兴奋性氨基酸损伤的化合物,结果显示,这些藏红花色素类化合物具有良好的保护H 2O 2和 L-谷氨酸所致细胞损伤的作用,由于氧化应激、兴奋性氨基酸显著升高是阿尔茨海默症神经损伤的重要因素,故这些化合物具有良好的防治阿尔茨海默症的作用并具有广阔的开发利用前景。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)