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1. (WO2017185758) PRIMER, PROBE, KIT, AND METHOD FOR MICROCHIMERISM ASSAY AND INDIVIDUAL RECOGNITION

Pub. No.:    WO/2017/185758    International Application No.:    PCT/CN2016/109157
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Sat Dec 10 00:59:59 CET 2016
IPC: C12Q 1/68
C12N 15/11
Applicants: SHANGHAI TISSUEBANK BIOTECHNOLOGY CO., LTD.
上海荻硕贝肯生物科技有限公司
SHANGHAI TISSUEBANK MEDICAL LABORATORY CO., LTD.
上海荻硕贝肯医学检验所有限公司
Inventors: ZHENG, Zhongzheng
郑仲征
DU, Jinwei
杜金伟
Title: PRIMER, PROBE, KIT, AND METHOD FOR MICROCHIMERISM ASSAY AND INDIVIDUAL RECOGNITION
Abstract:
A primer and probe combination used for a microchimerism assay and individual recognition, a kit comprising the primer and probe combination, and a method for implementing, by using the primer and probe combination or the kit, a microchimerism assay and individual recognition. The invention screens, by means of the latest InDel site database, and using an Asian population as the standard, 15 InDel sites with high powers of discrimination for the Asian population. The invention further includes, for each of the InDel sites, a design for a specific primer and probe combination. When compared to the prior art, the method provides the advantages of high polymorphism, good specificity, high sensitivity, ease of use, and rapidity, thereby offering an important method for implementing a microchimerism assay and individual recognition for an Asian population.