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1. (WO2017185165) GENE SIGNATURE FOR PROSTATE CANCER PROGNOSIS

Pub. No.:    WO/2017/185165    International Application No.:    PCT/CA2017/000095
Publication Date: Fri Nov 03 00:59:59 CET 2017 International Filing Date: Wed Apr 26 01:59:59 CEST 2017
IPC: C12Q 1/68
G01N 33/48
G06F 17/18
G06F 19/18
Applicants: ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
UNIVERSITY HEALTH NETWORK
Inventors: BOUTROS, Paul
BRISTOW, Robert G.
LALONDE, Emilie
Title: GENE SIGNATURE FOR PROSTATE CANCER PROGNOSIS
Abstract:
There is described herein a method for determining a risk of recurrence of cancer following a cancer therapy of a patient, comprising determining genomic instability of a tumour of the patient from a biopsy by identifying genome regions of the biopsy wherein the regions are at least loci rankings 1-15 of specific 31-loci and using copy number calls and calculating a plurality of statistical distances between the CNA tumour profile and a reference profile of recurring cancer patients to determine the risk of cancer recurrence following the cancer therapy of the patient.