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1. (WO2017185089) CANCER IMMUNOTHERAPY BY IMMUNE ACTIVATION OR IMMUNE MODULATION VIA GLOBO SERIES ANTIGENS

Pub. No.:    WO/2017/185089    International Application No.:    PCT/US2017/029138
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Tue Apr 25 01:59:59 CEST 2017
IPC: A61K 39/00
A61K 39/39
A61K 45/06
Applicants: OBI PHARMA, INC.
Inventors: SHUE, Youe-Kong
LIANG, Chen-Hsin
YU, Peiwen
CHEN, Chwen-Chen
YU, Cheng-Der, Tony
Title: CANCER IMMUNOTHERAPY BY IMMUNE ACTIVATION OR IMMUNE MODULATION VIA GLOBO SERIES ANTIGENS
Abstract:
The disclosure provides a method of immunotherapy for a cancer patient, comprises administering vaccines against Globo series antigens (i.e., Globo H, Stage-specific embryonic antigen 3 "SSEA3" and Stage-specific embryonic antigen 4 "SSEA4"). Specifically, the method comprises administering Globo H-KLH (OBI-822) in patients with Metastatic Breast Cancer. The disclosure also provides a method of comprises selecting a cancer patient who is suitable as treatment candidate for immunotherapy. In addition, the disclosure provides therapeutic agents, including monoclonal antibodies (mAbs) that bind specifically to Globo series antigens and related biomarkers useful in focusing such therapeutic and diagnostic regimens.