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1. (WO2017185062) PREDICTIVE BIOMARKERS FOR TAS-102 EFFICACY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/185062 International Application No.: PCT/US2017/028997
Publication Date: 26.10.2017 International Filing Date: 21.04.2017
IPC:
C12Q 1/68 (2006.01) ,G01N 33/574 (2006.01)
Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA[US/US]; 1150 South Olive Street, Suite 2300 Los Angeles, California 90015, US
Inventors: LENZ, Heinz-Josef; US
Agent: KONSKI, Antoinette F.; US
RAO, Photon; US
CHOI, Lydia; US
LIU, Cliff; US
SHELTON, Daniel; US
Priority Data:
62/326,61122.04.2016US
Title (EN) PREDICTIVE BIOMARKERS FOR TAS-102 EFFICACY
(FR) BIOMARQUEURS PRÉDICTIFS DE L'EFFICACITÉ DE TAS-102
Abstract: front page image
(EN) Methods are provided for identifying the clinical outcome of colorectal cancer patients following a therapy comprising TAS-102. The methods entails screening a cell or tissue sample isolated from the patient for a rs609429, rs861539, rs760370, or rs9394992 polymorphism. After determining if a patient is likely to be successfully treated, the disclosure also provides methods for treating the patient.
(FR) L'invention concerne des procédés pour identifier l'issue clinique de patients atteints d'un cancer colorectal après une thérapie comprenant du TAS-102. Ces procédés consistent à cribler un échantillon de cellules ou de tissu isolé à partir du patient pour détecter un polymorphisme de rs609429, rs861539, rs760370 ou rs9394992. Après avoir déterminé si le patient est susceptible d'être traité avec succès, l'invention concerne en outre des procédés pour traiter ces patients.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)