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1. WO2017184998 - A DEVICE FOR HIGH-THROUGHPUT MULTI-PARAMETER FUNCTIONAL PROFILING OF THE SAME CELLS IN MULTICELLULAR SETTINGS AND IN ISOLATION

Publication Number WO/2017/184998
Publication Date 26.10.2017
International Application No. PCT/US2017/028884
International Filing Date 21.04.2017
IPC
C12Q 1/02 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
G01N 33/48 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
CPC
B01L 2200/0668
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0647Handling flowable solids, e.g. microscopic beads, cells, particles
0668Trapping microscopic beads
B01L 2400/086
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2400Moving or stopping fluids
08Regulating or influencing the flow resistance
084Passive control of flow resistance
086using baffles or other fixed flow obstructions
B01L 3/502753
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
502753characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
C12M 23/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
23Constructional details, e.g. recesses, hinges
02Form or structure of the vessel
16Microfluidic devices; Capillary tubes
C12M 41/46
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
41Means for regulation, monitoring, measurement or control, e.g. flow regulation
46of cellular or enzymatic activity or functionality, e.g. cell viability
C12Q 1/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
Applicants
  • ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY [US]/[US]
Inventors
  • KELBAUSKAS, Laimonas
  • GLENN, Honor
  • HOUKAL, Jeff
  • ANDERSON, Clifford
  • TIAN, Yanqing
  • SU, Fengyu
  • MELDRUM, Deirdre
Agents
  • GUSTAFSON, Vincent, K.
Priority Data
62/326,45522.04.2016US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A DEVICE FOR HIGH-THROUGHPUT MULTI-PARAMETER FUNCTIONAL PROFILING OF THE SAME CELLS IN MULTICELLULAR SETTINGS AND IN ISOLATION
(FR) DISPOSITIF PERMETTANT LE PROFILAGE FONCTIONNEL À PLUSIEURS PARAMÈTRES ET À HAUT DÉBIT DES MÊMES CELLULES DANS DES INSTALLATIONS MULTICELLULAIRES ET EN ISOLEMENT
Abstract
(EN)
A device for high-throughput multi-parameter functional profiling of the same cells in multicellular settings and in isolation is provided. In certain aspects, an integrated microfluidic device for multi-parameter metabolic and other phenotypic profiling of live biological cells is useable with: 1 ) multicellular clusters or small biopsy tissue samples, 2) cultures of the constituent cells obtained after cluster/tissue dissociation, and 3) the same constituent single cells in isolation. The approach enables study of the effects of multicellular complexity, such as in response to treatment, pathogens, stress, or other factors concerning disease origination and progression. Measurements may be performed on single cells or multicellular populations or tissues in the same assay at the same time.
(FR)
L’invention concerne un dispositif permettant le profilage fonctionnel à plusieurs paramètres et à haut débit des mêmes cellules dans des installations multicellulaires et en isolement. Dans certains aspects, un dispositif microfluidique intégré permettant le profilage métabolique et d'autre profilages phénotypiques à plusieurs paramètres de cellules biologiques vivantes peut être utilisé avec : 1) des agrégats multicellulaires ou de petits échantillons de tissu de biopsie, 2) des cultures des cellules constitutives obtenues après dissociation des agrégats/tissus et 3) les mêmes cellules individuelles constitutives en isolement. L’approche permet d'étudier les effets de la complexité multicellulaire, tels qu’en réponse à un traitement, à des pathogènes, à un stress ou à d’autres facteurs concernant l’origine et la progression d’une maladie. Des mesures peuvent être effectuées sur des cellules individuelles ou sur des populations ou tissus multicellulaires dans le même essai simultanément.
Also published as
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