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1. (WO2017184875) COMPOSITION AND METHOD FOR TREATING METABOLIC DISORDERS

Pub. No.:    WO/2017/184875    International Application No.:    PCT/US2017/028656
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Fri Apr 21 01:59:59 CEST 2017
IPC: A61K 31/48
A61K 31/4985
C07D 457/06
A61P 3/00
A61P 43/00
Applicants: VEROSCIENCE LLC
Inventors: CINCOTTA, Anthony H.
Title: COMPOSITION AND METHOD FOR TREATING METABOLIC DISORDERS
Abstract:
Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e.g., the long-term modification and regulation of metabolic disorders, including prediabetes, obesity, insulin resistance, hyperinsulinemia, hyperglycemia and type 2 diabetes mellitus (T2DM) and/or, e.g., the treatment of other medical disorder(s) including immune or endocrine disorders or diseases. Bromocriptine citrate is administered over a limited or extended period at a time of day dependent on re-establishing the normal circadian rhythm of central dopaminergic activity of healthy members of a similar species and sex. Insulin resistance, hyperinsulinemia and hyperglycemia, T2DM, prediabetes, MS or all, can be controlled in humans on a long term basis by such treatment inasmuch as the daily administration of bromocriptine citrate resets neuronal activity timing in the neural centers of the brain to produce long term effects.