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1. (WO2017184832) COMPOSITIONS AND METHODS FOR MAKING ANTIBODIES BASED ON USE OF EXPRESSION-ENHANCING LOCI
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/184832 International Application No.: PCT/US2017/028555
Publication Date: 26.10.2017 International Filing Date: 20.04.2017
IPC:
C07K 16/00 (2006.01) ,C07K 16/46 (2006.01) ,C12N 15/90 (2006.01)
Applicants: REGENERON PHARMACEUTICALS, INC.[US/US]; 777 Old Saw Mill River Road Tarrytown, NY 10591-6707, US
Inventors: BABB, Robert; US
BURAKOV, Darya; US
CHEN, Gang; US
FANDL, James, P.; US
ZHAO, Yu; US
Agent: GROLZ, Edward, W.; US
Priority Data:
62/325,40020.04.2016US
Title (EN) COMPOSITIONS AND METHODS FOR MAKING ANTIBODIES BASED ON USE OF EXPRESSION-ENHANCING LOCI
(FR) COMPOSITIONS ET PROCÉDÉS DE PRODUCTION D'ANTICORPS BASÉS SUR L'UTILISATION DE LOCI D’AMÉLIORATION DE L'EXPRESSION
Abstract:
(EN) This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antigen-binding proteins including monospecific and bispecifc antibodies in eukaryotic cells, particularly Chinese hamster (Cricetulus griseus) cell lines, by employing multiple expression-enhancing locus.
(FR) L'invention concerne l'intégration et l'expression spécifiques de site de protéines recombinées dans des cellules eucaryotes. En particulier, l'invention concerne des compositions et des procédés permettant une expression améliorée des protéines se liant à l'antigène comprenant des anticorps monospécifiques et bispécifiques chez les cellules eucaryotes, en particulier les lignées cellulaires de hamster chinois (Cricetulus griseus), par utilisation de multiples loci d'amélioration de l'expression.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)