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1. (WO2017184831) COMPOSITIONS AND METHODS FOR MAKING ANTIBODIES BASED ON USE OF AN EXPRESSION-ENHANCING LOCUS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/184831    International Application No.:    PCT/US2017/028552
Publication Date: 26.10.2017 International Filing Date: 20.04.2017
IPC:
C07K 16/00 (2006.01), C07K 16/46 (2006.01), C12N 15/90 (2006.01)
Applicants: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 (US)
Inventors: BABB, Robert; (US).
BURAKOV, Darya; (US).
CHEN, Gang; (US).
FANDL, James, P.; (US)
Agent: GROLZ, Edward, W.; (US)
Priority Data:
62/325,385 20.04.2016 US
Title (EN) COMPOSITIONS AND METHODS FOR MAKING ANTIBODIES BASED ON USE OF AN EXPRESSION-ENHANCING LOCUS
(FR) COMPOSITIONS ET PROCÉDÉS DE FABRICATION D'ANTICORPS BASÉS SUR L'UTILISATION D'UN LOCUS RENFORÇANT L'EXPRESSION
Abstract: front page image
(EN)This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antibodies including bispecifc antibodies in eukaryotic cells, particularly Chinese hamster (Cricetulus griseus) cell lines, by employing an expression-enhancing locus.
(FR)L'invention concerne l'intégration et l'expression spécifiques à un site de protéines recombinantes dans des cellules eucaryotes. En particulier, l'invention concerne des compositions et des procédés pour une expression améliorée d'anticorps, dont des anticorps bispécifiques exprimés dans des cellules eucaryotes, notamment dans des lignées cellulaires de hamster chinois (Cricetulus griseus), en utilisant un locus qui permet de renforcer l'expression.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)