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1. (WO2017184774) HDAC INHIBITORS, ALONE OR IN COMBINATION WITH BTK INHIBITORS, FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA

Pub. No.:    WO/2017/184774    International Application No.:    PCT/US2017/028435
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Thu Apr 20 01:59:59 CEST 2017
IPC: A61K 31/506
A61K 31/4162
A61P 35/02
C07D 239/42
Applicants: ACETYLON PHARMACEUTICALS, INC.
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Inventors: JONES, Simon, S.
QUAYLE, Steven, N.
SAHAKIAN, Eva
IBARZ, Javier, Pinilla
Title: HDAC INHIBITORS, ALONE OR IN COMBINATION WITH BTK INHIBITORS, FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA
Abstract:
Disclosed are histone deacetylase (HDAC) inhibitors, or combinations comprising an HDAC inhibitor and a Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of chronic lymphocytic leukemia in a subject in need thereof. Also provided herein are methods for treating chronic lymphocytic leukemia in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor, or a combination comprising an HDAC inhibitor and a BTK inhibitor. Other related methods are disclosed.