WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2017184677) METHOD AND SYSTEM OF NANOPORE-BASED INFORMATION ENCODING
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/184677    International Application No.:    PCT/US2017/028272
Publication Date: 26.10.2017 International Filing Date: 19.04.2017
IPC:
C12Q 1/68 (2006.01), C07K 14/31 (2006.01), C12N 9/96 (2006.01), C12N 9/12 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, Massachusetts 02138 (US)
Inventors: CHURCH, George M.; (US).
PALLA, Mirkó; (US).
STRANGES, Peter Benjamin; (US).
NIVALA, Jeffrey Matthew; (US)
Agent: IWANICKI, John P.; (US)
Priority Data:
62/325,669 21.04.2016 US
Title (EN) METHOD AND SYSTEM OF NANOPORE-BASED INFORMATION ENCODING
(FR) MÉTHODE ET SYSTÈME DE CODAGE D'INFORMATIONS À BASE DE NANOPORES
Abstract: front page image
(EN)This invention provides methods and systems of DNA synthesis including providing an encoding unit comprising an enzyme, a single-stranded DNA (ssDNA) and a nanopore, providing a lipid bilayer having on opposite sides a cis and a trans reservoir each having a different buffer composition, wherein the nanopore is within the lipid bilayer and the enzyme and the ssDNA are in the cis reservoir, providing an electrode over the lipid bilayer wherein the electrode can modulate voltage across the lipid bilayer, wherein the enzyme catalyzes DNA synthesis in response to the voltage..
(FR)L'invention concerne des méthodes et des systèmes de synthèse d'ADN consistant à fournir une unité de codage comprenant une enzyme, un ADN monocaténaire (ADNsb) et un nanopore, à fournir une bicouche lipidique comportant sur ses faces opposées un réservoir cis et un réservoir trans comprenant chacun une composition tampon différente, le nanopore se trouvant à l'intérieur de la bicouche lipidique et l'enzyme et l'ADNsb se trouvant dans le réservoir cis, à fournir une électrode sur la bicouche lipidique, l'électrode pouvant moduler la tension au sein de la bicouche lipidique, l'enzyme catalysant la synthèse d'ADN en réponse à la tension.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)