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Machine translation
1. (WO2017184562) CMV NEUTRALIZING ANTIGEN BINDING PROTEINS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/184562    International Application No.:    PCT/US2017/028062
Publication Date: 26.10.2017 International Filing Date: 18.04.2017
IPC:
A61K 39/00 (2006.01), A61K 39/245 (2006.01), A61K 39/395 (2006.01), A61K 39/42 (2006.01), C12N 7/00 (2006.01), C12P 21/00 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US).
THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street Austin, Texas 78701 (US).
FU, Tong-Ming [US/US]; (US) (US only).
TANG, Aimin [US/US]; (US) (US only).
WANG, Dai [US/US]; (US) (US only).
AN, Zhiqiang [US/US]; (US) (US only).
ZHANG, Ningyan [US/US]; (US) (US only).
HA, Sha [US/US]; (US) (US only)
Inventors: FU, Tong-Ming; (US).
TANG, Aimin; (US).
WANG, Dai; (US).
AN, Zhiqiang; (US).
ZHANG, Ningyan; (US).
HA, Sha; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
62/324,952 20.04.2016 US
Title (EN) CMV NEUTRALIZING ANTIGEN BINDING PROTEINS
(FR) PROTÉINES DE LIAISON À UN ANTIGÈNE DE NEUTRALISATION DES CMV
Abstract: front page image
(EN)The present invention is directed to antigen binding proteins including, but not limited to, monoclonal antibodies and antigen binding fragments thereof, that specifically bind to and preferably neutralize human cytomegalovirus (CMV). The antigen binding proteins of the invention are useful as a prophylactic and/or therapeutic agent for preventing and/or treating CMV infections in a patient in need thereof. Also encompassed by the invention are pharmaceutical compositions comprising the antigen binding proteins of the invention and a pharmaceutically acceptable carrier. The invention further relates to methods of using the antigen binding proteins and pharmaceutical compositions of the invention for the prevention or treatment of CMV infection in patients in need thereof.
(FR)La présente invention concerne des protéines de liaison à un antigène comprenant, entre autres, des anticorps monoclonaux et des fragments de ceux-ci de liaison à l'antigène, qui se lient spécifiquement au cytomégalovirus humain (CMV) et neutralisent celui-ci de préférence. Les protéines de liaison à l'antigène de l'invention sont utiles en tant qu'agent prophylactique et/ou thérapeutique permettant de prévenir et/ou de traiter des infections par le CMV chez un patient qui en a besoin. L'invention concerne également des compositions pharmaceutiques comprenant les protéines de liaison à l'antigène de l'invention et un excipient pharmaceutiquement acceptable. L'invention concerne en outre des méthodes d'utilisation des protéines de liaison à l'antigène et des compositions pharmaceutiques de l'invention pour la prévention ou le traitement d'une infection par le CMV chez des patients qui en ont besoin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)