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Pub. No.:    WO/2017/184491    International Application No.:    PCT/US2017/027889
Publication Date: 26.10.2017 International Filing Date: 17.04.2017
C07D 249/04 (2006.01), C07D 401/04 (2006.01)
Applicants: CELGENE QUANTICEL RESEARCH, INC. [US/US]; 9393 Towne Centre Drive, Suite 110 San Diego, California 92121 (US)
Inventors: NIE, Zhe; (US).
STAFFORD, Jeffrey A.; (US).
VEAL, James M.; (US).
WALLACE, Michael B.; (US)
Agent: SUNG, Lawrence; (US).
SYLVIA, Mary; (US)
Priority Data:
62/324,813 19.04.2016 US
Abstract: front page image
(EN)The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.
(FR)La présente invention concerne des composés dérivés triazolylpyridines substitués, et des compositions pharmaceutiques comprenant lesdits composés. Les composés et compositions de l’invention sont utiles pour moduler l’activité des enzymes histones déméthylases. De manière additionnelle, les composés et les compositions de l’invention sont utiles pour le traitement du cancer ou d’autres maladies néoplasiques, ou maladies associées à l’activité anormale de l’histone déméthylase. En conséquence, les composés dérivés triazolylpyridines subsitués décrits ici sont utiles dans les procédés et les médicaments de traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)