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1. (WO2017184462) THERAPEUTIC COMPOUNDS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/184462 International Application No.: PCT/US2017/027815
Publication Date: 26.10.2017 International Filing Date: 14.04.2017
IPC:
C07D 239/28 (2006.01) ,C07D 403/12 (2006.01)
Applicants: CELGENE QUANTICEL RESEARCH, INC.[US/US]; 9393 Towne Centre Drive, Suite 110 San Diego, California 92121, US
Inventors: BENNETT, Michael J.; US
BETANCORT, Juan M.; US
BOLOOR, Amogh; US
KANOUNI, Toufike A.; US
STAFFORD, Jeffrey A.; US
VEAL, James M.; US
WALLACE, Michael B.; US
Agent: SUNG, Lawrence M.; US
SYLVIA, Mary; US
Priority Data:
62/324,27918.04.2016US
Title (EN) THERAPEUTIC COMPOUNDS
(FR) COMPOSÉS THÉRAPEUTIQUES
Abstract:
(EN) The present disclosure relates to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease
(FR) La présente invention concerne des composés thérapeutiques dérivés hétérocycliques substitués, des compositions comprenant lesdits composés, et l'utilisation desdits composés et desdites compositions pour la régulation épigénétique par inhibition de reconnaissance induite par bromodomaine de régions acétyl-lysine de protéines, telles que des histones. Ces compositions et procédés sont utiles pour le traitement de maladies médiées par une signalisation cellulaire aberrante, telles que des troubles inflammatoires, un cancer et une maladie néoplasique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)