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1. (WO2017184436) SYSTEMS AND METHODS FOR STEROIDAL GELS

Pub. No.:    WO/2017/184436    International Application No.:    PCT/US2017/027520
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Sat Apr 15 01:59:59 CEST 2017
IPC: A61K 9/06
A61K 31/573
A61K 47/04
Applicants: CHILDREN'S MEDICAL CENTER CORPORATION
Inventors: KOHANE, Daniel, S.
LIU, Qian
Title: SYSTEMS AND METHODS FOR STEROIDAL GELS
Abstract:
The present invention generally relates to compositions, such as gels comprising steroids. In certain aspects, the steroids are modified such that they can form gels, e.g., when complexed to metal ions. In some cases, the steroids form fibers, such as nanofibers, within the gel. For instance, in one set of embodiments, a steroid may be relatively hydrophobic, and/or modified to include a phosphate moiety that is able to complex to metal ions to form the gel. In some cases, such gels may be administered to a subject, e.g., through injection. Other aspects of the invention are generally directed to methods of making or using such gels, kits comprising such gels, or the like.