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1. (WO2017184355) FORMULATIONS OF ABALOPARATIDE, TRANSDERMAL PATCHES THEREOF, AND USES THEREOF
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Pub. No.: WO/2017/184355 International Application No.: PCT/US2017/026462
Publication Date: 26.10.2017 International Filing Date: 06.04.2017
IPC:
A61K 38/29 (2006.01) ,A61K 9/70 (2006.01) ,A61K 47/04 (2006.01) ,C07K 14/635 (2006.01)
Applicants: RADIUS HEALTH, INC.[US/US]; 950 Winter Street Waltham, MA 02451, US
Inventors: HATTERSLEY, Gary; US
HARRIS, Alan; US
SAEH, Jamal; US
HAMED, Ehab; US
Agent: WANG, Yingli; US
Priority Data:
62/324,33618.04.2016US
62/353,24922.06.2016US
62/396,19618.09.2016US
62/479,25030.03.2017US
PCT/US2016/05619608.10.2016US
Title (EN) FORMULATIONS OF ABALOPARATIDE, TRANSDERMAL PATCHES THEREOF, AND USES THEREOF
(FR) FORMULATIONS D’ABALOPARATIDE, TIMBRES TRANSDERMIQUES LES CONTENANT, ET UTILISATIONS DE CELLES-CI
Abstract:
(EN) Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.
(FR) La présente invention concerne des formulations d’abaloparatide pour l’administration transdermique d’une quantité thérapeutiquement efficace d’abaloparatide, ainsi que des timbres transdermiques préparés à l’aide de ces formulations, des procédés de préparation des formulations et des timbres selon l’invention, et des méthodes d’utilisation de ces formulations et timbres pour traiter l’ostéoporose, l’ostéopénie, l’arthrose et/ou une fracture osseuse, améliorer la densité minérale osseuse (DMO), améliorer le score d’os trabéculaire (TBS), et traiter, prévenir et/ou réduire des fractures osseuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)