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1. (WO2017184334) GENERATION OF GENETICALLY ENGINEERED ANIMALS BY CRISPR/CAS9 GENOME EDITING IN SPERMATOGONIAL STEM CELLS

Pub. No.:    WO/2017/184334    International Application No.:    PCT/US2017/026070
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Thu Apr 06 01:59:59 CEST 2017
IPC: C12N 5/00
C12N 15/10
C12N 15/00
A61K 48/00
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventors: HAMRA, Franklin, Kent
Title: GENERATION OF GENETICALLY ENGINEERED ANIMALS BY CRISPR/CAS9 GENOME EDITING IN SPERMATOGONIAL STEM CELLS
Abstract:
The present disclosure provides methods and compositions for the production of genetically engineered animals, such as mice, by genomic editing of the spermatogonial stem cells, such as by using the CRISPR/Cas9 gene editing system. Also provided are methods of studying gene function and creating disease models.