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1. (WO2017184059) MARKER GENES FOR COLORECTAL CANCER CLASSIFICATION, METHOD FOR JUDGING LYMPH NODE METASTASIS FOR PROGNOSIS OF COLORECTAL CANCER AND KIT THEREFOR

Pub. No.:    WO/2017/184059    International Application No.:    PCT/SE2017/050368
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Thu Apr 13 01:59:59 CEST 2017
IPC: G01N 33/574
C12Q 1/68
Applicants: HILOPROBE AB
Inventors: OLSSON, Lina
HAMMARSTRÖM, Sten
HAMMARSTRÖM, Marie-Louise
LINDMARK, Gudrun
ISRAELSSON, Anne
Title: MARKER GENES FOR COLORECTAL CANCER CLASSIFICATION, METHOD FOR JUDGING LYMPH NODE METASTASIS FOR PROGNOSIS OF COLORECTAL CANCER AND KIT THEREFOR
Abstract:
The present invention provides a group of molecular biomarkers, comprising the genes SLC35 D3, POSTN, KLK6 and MUC2, for use in objective and quantitative methods for the classification, prediction of prognosis and for guiding treatment decisions of a subject with colorectal cancer. More specifically the present invention provides methods for determining the metastatic potential and/or tumor aggressiveness of a colorectal cancer in a subject, comprising determining the gene expression levels of genes SLC35D3, POSTN, KLK6 and/or MUC2 in a regional lymph node, a primary intestinal tumor, blood, or faeces sample obtained from the subject.