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1. WO2017183746 - PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ATRAUMATIC INTRACEREBRAL HEMORRHAGE, COMPRISING CERIA NANOCOMPOSITE

Publication Number WO/2017/183746
Publication Date 26.10.2017
International Application No. PCT/KR2016/004123
International Filing Date 20.04.2016
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 33/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61K 47/10 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols ; Poloxamers; PEG/POE alkyl ethers
A61K 47/18 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/30 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
CPC
A61K 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 47/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
Applicants
  • 서울대학교병원 SEOUL NATIONAL UNIVERSITIY HOSPITAL [KR]/[KR]
  • 서울대학교 산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR]/[KR]
  • 기초과학연구원 INSTITUTE FOR BASIC SCIENCE [KR]/[KR]
Inventors
  • 이승훈 LEE, Seung-Hoon
  • 현택환 ΗΥΕΟΝ, Taeghwan
  • 김치경 KIM, Chi Kyung
  • 강동완 KANG, Dong-Wan
  • 소민 SOH, Min
Agents
  • 제일특허법인 FIRSTLAW P.C.
Priority Data
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ATRAUMATIC INTRACEREBRAL HEMORRHAGE, COMPRISING CERIA NANOCOMPOSITE
(FR) COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT D'UNE HÉMORRAGIE INTRACÉRÉBRALE ATRAUMATIQUE, COMPRENANT UN NANOCOMPOSITE D'OXYDE DE CÉRIUM
(KO) 세리아 나노복합체를 포함하는 비외상성 두개내 출혈 치료용 약학적 조성물
Abstract
(EN)
The present invention relates to a pharmaceutical composition for treating atraumatic intracerebral hemorrhage, comprising a ceria nanocomposite. The pharmaceutical composition comprising a ceria nanocomposite, of the present invention, efficiently reaches the inside of the cytoplasm through the cell membrane and exhibits excellent antioxidative and antiinflammatory effects in the hematoma and the surrounding region thereof. Therefore, the pharmaceutical composition can be usefully used for the treatment of atraumatic intracerebral hemorrhage.
(FR)
La présente invention concerne une composition pharmaceutique pour le traitement d'une hémorragie intracérébrale atraumatique, comprenant un nanocomposite d'oxyde de cérium. La composition pharmaceutique comprenant un nanocomposite d'oxyde de cérium, de la présente invention, atteint efficacement l'intérieur du cytoplasme à travers la membrane cellulaire et présente d'excellents effets antioxydants et anti-inflammatoires dans l'hématome et la région entourant celui-ci. Par conséquent, la composition pharmaceutique peut être utilement employée pour le traitement d'une hémorragie intracérébrale atraumatique.
(KO)
본 발명은 세리아 나노복합체를 포함하는 비외상성 두개내 출혈 치료용 약학적 조성물에 관한 것으로서, 본 발명의 세리아 나노복합체를 포함하는 약학적 조성물은, 세포막을 통과하여 세포질 내에 효율적으로 도달해, 혈종 및 혈종 주변 부위에서 우수한 항산화 및 항염증 효과를 나타내므로, 비외상성 두개내 출혈 치료에 유용하게 사용될 수 있다.
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