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1. (WO2017183676) METHOD FOR EVALUATING ANGIOGENESIS INHIBITORY ACTIVITY OF TEST COMPOUND

Pub. No.:    WO/2017/183676    International Application No.:    PCT/JP2017/015807
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Thu Apr 20 01:59:59 CEST 2017
IPC: C12Q 1/02
C12M 1/34
C12N 5/071
Applicants: TOPPAN PRINTING CO., LTD.
凸版印刷株式会社
Inventors: TSUKAMOTO Kei
塚本 圭
KITANO Shiro
北野 史朗
IRIE Shinji
入江 新司
Title: METHOD FOR EVALUATING ANGIOGENESIS INHIBITORY ACTIVITY OF TEST COMPOUND
Abstract:
Provided is a method for evaluating the angiogenesis inhibitory activity of a test compound, the method comprising: a culturing step for culturing, in the presence of the test compound, a cell structure having a vascular network structure; and an evaluation step for evaluating whether or not the test compound has angiogenesis inhibitory activity, by using, as an index, the state of vessels in the cell structure cultured in the culturing step, wherein, in the evaluation step, when the number of cells constituting the vessels in the cell structure is small or the vascular network structure in the cell structure is damaged compared to the case in which the cell structure is cultured in the absence of the test compound, the test compound is evaluated to have angiogenesis inhibitory activity.