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1. (WO2017182916) NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/182916    International Application No.:    PCT/IB2017/052108
Publication Date: 26.10.2017 International Filing Date: 12.04.2017
IPC:
C07D 455/06 (2006.01)
Applicants: LUPIN LIMITED [IN/IN]; Kalpataru Inspire, 3rd Floor, Off Western Express Highway, Santacruz (East), Maharashtra, Mumbai 400 055 (IN)
Inventors: DESPANDE, Tushar, Nandkumar; (IN).
SINGARE, Dnyaneshwar, Tukaram; (IN).
PAWAR, Yogesh, Dadaji; (IN).
CHAVAN, Yuvraj, Atmaram; (IN).
RAY, Purna Chandra; (IN).
SINGH, Girij, Pal; (IN)
Agent: MAJUMDAR, Subhatosh; (IN).
GANGULI, Dr., Sanchita; (IN).
SEN, Abhishek; (IN).
VENKATESH, Mythili; (IN).
MAJUMDAR, Amrita; (IN).
KUNDU, Subarna; (IN).
CHAUBEY, Priyanka; (IN)
Priority Data:
201621014182 22.04.2016 IN
Title (EN) NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE
(FR) NOUVEAU PROCÉDÉ DE PRÉPARATION DE LA TÉTRABÉNAZINE ET DE LA DEUTÉTRABÉNAZINE
Abstract: front page image
(EN)The present invention provides process for preparation of dihydroxy benzoquinoline compound (III) comprising reacting dihydroxy isoquinoline compound (IV) or a salt thereof with (2-acetyl-4-methyl-pentyl)-trimethyl-ammonium iodide (V) and further 5 converting it to tetrabenazine (I) and deutetrabenazine (II).
(FR)La présente invention concerne un procédé de préparation d'un composé dihydroxy-benzoquinoline (III) consistant à faire réagir un composé dihydroxy-isoquinoline (IV) ou un sel correspondant avec l'iodure de (2-acétyl-4-méthyl-pentyl)-triméthyl-ammonium (V), puis à convertir celui-ci en tétrabénazine (I) et en deutétrabénazine (II).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)