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1. (WO2017182916) NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/182916 International Application No.: PCT/IB2017/052108
Publication Date: 26.10.2017 International Filing Date: 12.04.2017
IPC:
C07D 455/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
455
Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
03
containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
04
containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
06
containing benzo [a] quinolizine ring systems
Applicants: LUPIN LIMITED[IN/IN]; Kalpataru Inspire, 3rd Floor, Off Western Express Highway, Santacruz (East), Maharashtra, Mumbai 400 055, IN
Inventors: DESPANDE, Tushar, Nandkumar; IN
SINGARE, Dnyaneshwar, Tukaram; IN
PAWAR, Yogesh, Dadaji; IN
CHAVAN, Yuvraj, Atmaram; IN
RAY, Purna Chandra; IN
SINGH, Girij, Pal; IN
Agent: MAJUMDAR, Subhatosh; IN
GANGULI, Dr., Sanchita; IN
SEN, Abhishek; IN
VENKATESH, Mythili; IN
MAJUMDAR, Amrita; IN
KUNDU, Subarna; IN
CHAUBEY, Priyanka; IN
Priority Data:
20162101418222.04.2016IN
Title (EN) NOVEL PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE
(FR) NOUVEAU PROCÉDÉ DE PRÉPARATION DE LA TÉTRABÉNAZINE ET DE LA DEUTÉTRABÉNAZINE
Abstract:
(EN) The present invention provides process for preparation of dihydroxy benzoquinoline compound (III) comprising reacting dihydroxy isoquinoline compound (IV) or a salt thereof with (2-acetyl-4-methyl-pentyl)-trimethyl-ammonium iodide (V) and further 5 converting it to tetrabenazine (I) and deutetrabenazine (II).
(FR) La présente invention concerne un procédé de préparation d'un composé dihydroxy-benzoquinoline (III) consistant à faire réagir un composé dihydroxy-isoquinoline (IV) ou un sel correspondant avec l'iodure de (2-acétyl-4-méthyl-pentyl)-triméthyl-ammonium (V), puis à convertir celui-ci en tétrabénazine (I) et en deutétrabénazine (II).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)