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1. (WO2017182828) ANTIMICROBIAL AGENTS

Pub. No.:    WO/2017/182828    International Application No.:    PCT/GB2017/051124
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Sat Apr 22 01:59:59 CEST 2017
IPC: C07C 69/732
C07C 235/28
A61K 31/232
A61P 31/00
C12N 1/00
Applicants: THE UNIVERSITY OF WARWICK
Inventors: CHALLIS, Gregory Leonard
GRIFFITHS, Daniel John
MASSCHELEIN, Joleen Solange Liesbet
Title: ANTIMICROBIAL AGENTS
Abstract:
The invention provides novel compounds of formula (I) and their pharmaceutically acceptable salts, metabolites, isomers (e.g. stereoisomers) and prodrugs. Such compounds are effective in the treatment of infections caused by Gram-negative bacteria such as Acinetobacter baumannii. In formula (I), X is O, NR (where R is either H or C1-3 alkyl, e.g. CH3), or CH2; R3 is H, F, CI, Br, I, or CH3; R4 is H, or OH; R5 and R6 are independently selected from H and OH, or R5 and R6 together are =O; R7 is H, F, CI, Br, I, or CH3; R8 is H, OH, or -OC(O)NR'2 (where each R' is independently H or C1-3 alkyl, e.g. CH3), preferably R8 is H, OH or -OC(O)NH2; R9 is a 5- or 6-membered, saturated or unsaturated, carbocyclic ring optionally substituted by one or more substituents, or R9 is an optionally substituted straight-chained or branched C1-6 alkyl group (e.g. C1-3 alkyl group); R10 is a straight-chained or branched C1-8 alkyl group (e.g. C1-6 alkyl group), a C4-6 cycloalkyl group, or an optionally substituted aryl or heteroaryl group; and each --- independently represents an optional bond (i.e. each of C2-C3, C4-C5, C6-C7, C8-C9, C10-C11 and C18-C19 are independently either C-C (single) or C=C (double) bonds).