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1. (WO2017182705) HUMANIZED ANTI CLEVER-1 ANTIBODIES AND THEIR USE

Pub. No.:    WO/2017/182705    International Application No.:    PCT/FI2017/050285
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Wed Apr 19 01:59:59 CEST 2017
IPC: C07K 16/28
G01N 33/50
A61K 39/00
Applicants: FARON PHARMACEUTICALS OY
Inventors: MAKSIMOW, Mikael
JALKANEN, Markku
VAINIO, Marita
Title: HUMANIZED ANTI CLEVER-1 ANTIBODIES AND THEIR USE
Abstract:
This invention relates to an agent and a humanized antibody or single chain Fv or Fab fragment capable of binding to human CLEVER-1 recognizing an epitope of CLEVER-1, wherein the epitope is discontinuous and comprises the sequences: PFTVLVPSVSSFSSR and QEITVTFNQFTK. This invention relates also an agent capable of binding to an epitope of human CLEVER-1 for use in removing tumour or antigen induced immunosuppression. Further, the invention relates to a pharmaceutical composition comprising the agent capable of binding to human CLEVER-1 and an appropriate excipient.