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1. (WO2017182464) NEW AZA- TETRACYCLO DERIVATIVES
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Pub. No.: WO/2017/182464 International Application No.: PCT/EP2017/059178
Publication Date: 26.10.2017 International Filing Date: 18.04.2017
IPC:
C07D 401/14 (2006.01) ,A61K 31/403 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 31/454 (2006.01) ,C07D 401/06 (2006.01) ,C07D 409/06 (2006.01) ,C07D 409/14 (2006.01) ,C07D 209/70 (2006.01) ,C07D 209/72 (2006.01) ,A61P 3/00 (2006.01) ,A61P 9/00 (2006.01) ,A61P 25/00 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
454
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
58
[b]- or [c]-condensed
70
containing carbocyclic rings other than six-membered
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
58
[b]- or [c]-condensed
72
4,7-Endo-alkylene-iso-indoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants: CIDQO 2012, S.L.[ES/ES]; Polígono Industrial Can Verdalet, Carred D, Nau 91 E-08490 Tordera - Barcelona, ES
UNIVERSITAT DE BARCELONA[ES/ES]; Centro de Patentes UB Baldiri Reixac, 4, Torre D E-08028 Barcelona, ES
Inventors: VÁZQUEZ CRUZ, Santiago; ES
LEIVA MARTÍNEZ, Rosana; ES
VALVERDE MURILLO, Elena; ES
Agent: CARBONELL VALLÈS, Enric; ES
Priority Data:
16382175.419.04.2016EP
Title (EN) NEW AZA- TETRACYCLO DERIVATIVES
(FR) NOUVEAUX DÉRIVÉS D'AZA-TÉTRACYCLO
Abstract:
(EN) The present invention relates to compounds of formula (I); which are capable of inhibiting the 11-beta-hydroxysteroid dehydrogenase type 1 (11- beta-HSD1), to processes for preparing these compounds, to pharmaceutical compositions comprising an effective amount of these compounds, to the use of the compounds in medicine in particular for the treatment of pathological conditions or diseases that can improve by inhibition of 11-beta-HSD1, to the use of said compound for the manufacture of a medicament for the treatment of pathological conditions or diseases that can improve by inhibition of 11-beta-HSD1 and to methods for the treatment or prevention of a disease or conditions susceptible of improvement by inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11β-HD1) in a subject in need thereof comprising the administration to said subject of a therapeutically effective amount of said compounds.
(FR) La présente invention concerne des composés de formule (I) qui sont capables d'inhiber la 11-bêta-hydroxystéroïde déshydrogénase de type 1 (11-bêta-HSD1), des procédés de préparation de ces composés, des compositions pharmaceutiques comprenant une quantité efficace de ces composés, l'utilisation de ces composés en médecine, en particulier pour le traitement d'affections pathologiques ou de maladies qui peuvent être améliorées par l'inhibition de la 11-bêta-HSD1, l'utilisation dudit composé pour la fabrication d'un médicament pour le traitement d'affections pathologiques ou de maladies qui peuvent être améliorées par inhibition de la 11-bêta-HSD1 et des procédés pour le traitement ou la prévention d'une maladie ou d'une affection susceptible d'être améliorée par l'inhibition de la 11β-hydroxystéroïde déshydrogénase de type 1 (11β-HD1) chez un sujet en ayant besoin, consistant à administrer audit sujet une quantité thérapeutiquement efficace desdits composés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)