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1. (WO2017182208) IN VITRO FULL-SKIN MODEL CONTAINING THREE-DIMENSIONAL CELL CULTURE MODELS OF THE SWEAT GLAND

Pub. No.:    WO/2017/182208    International Application No.:    PCT/EP2017/056490
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Tue Mar 21 00:59:59 CET 2017
IPC: C12N 5/071
Applicants: HENKEL AG & CO. KGAA
Inventors: KLAKA, Patricia
GRÜDL, Sabine
GIESEN, Melanie
WELSS, Thomas
BANOWSKI, Bernhard
VIERKOTTEN, Lars
Title: IN VITRO FULL-SKIN MODEL CONTAINING THREE-DIMENSIONAL CELL CULTURE MODELS OF THE SWEAT GLAND
Abstract:
The invention relates to an in vitro full-skin model comprising, on a substrate layer, a dermis equivalent, an epidermis equivalent, and 1 to 100 three-dimensional sweat gland equivalents, each of which has 500 to 500,000 sweat gland cells and a diameter of 100 to 6,000 μm. The invention further relates to the production of the full-skin model and the use of said model as an in vitro model, in screening processes and for in vitro assessment of the effect of cosmetic substances on the inhibition of secretion of sweat and on body odor.