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1. (WO2017181973) 5-MEMBER HETEROCYCLE AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
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Pub. No.: WO/2017/181973 International Application No.: PCT/CN2017/081293
Publication Date: 26.10.2017 International Filing Date: 20.04.2017
IPC:
C07D 409/04 (2006.01) ,C07D 487/04 (2006.01) ,C07D 471/04 (2006.01) ,C07D 401/04 (2006.01) ,C07D 403/04 (2006.01) ,C07D 413/04 (2006.01) ,A61K 31/4025 (2006.01) ,A61K 31/437 (2006.01) ,A61K 31/519 (2006.01) ,A61K 31/506 (2006.01) ,A61P 35/00 (2006.01)
Applicants: SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.[CN/CN]; Floor 10, Building D, No. 398, Ruoshui Road, Suzhou Industrial Park Suzhou, Jiangsu 215123, CN
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES[CN/CN]; 555 Zu Chong Zhi Road, Zhang Jiang, Pudong Shanghai 201203, CN
Inventors: LUO, Cheng; CN
YAO, Zhiyi; CN
QIAO, Gang; CN
JIANG, Hualiang; CN
ZHOU, Yu; CN
CHEN, Limin; CN
LIU, Jingqiu; CN
DING, Hong; CN
Agent: XU & PARTNERS, LLC.; Room No.106, Building No.1, Universal High-Tech Plaza,958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201610247658.120.04.2016CN
201610880966.809.10.2016CN
Title (EN) 5-MEMBER HETEROCYCLE AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
(FR) HÉTÉROCYCLE À 5 CHAÎNONS ET PROCÉDÉ DE FABRICATION, COMPOSITION PHARMACEUTIQUE, ET SON APPLICATION
(ZH) 五元杂环类化合物及其制备方法、药物组合物和用途
Abstract: front page image
(EN) The invention provides a 5-member heterocycle and a manufacturing method, pharmaceutical composition, and application thereof. Specifically, the invention provides a compound represented by formula (I). Various radicals are as defined in the specification. The compound represented by formula (I) is effective in inhibiting an activity of a tubulin and can be used to prepare a pharmaceutical product for treating or preventing a mammalian disease related to a tubulin abnormality.
(FR) La présente invention décrit un hétérocycle à 5 chaînons et un procédé de fabrication, une composition pharmaceutique, et son application. Spécifiquement, l'invention décrit un composé représenté par la formule (I). Divers radicaux sont tels que définis dans la description. Le composé représenté par la formule (I) est efficace dans l'inhibition d'une activité d'une tubuline et peut être utilisé pour préparer un produit pharmaceutique destiné au traitement ou à la prévention d'une maladie chez un mammifère liée à une anomalie concernant la tubuline.
(ZH) 本发明提供了一类五元杂环类化合物及其制备方法、药物组合物和用途,具体地,本发明提供了一类具有如下式(I)化合物,其中,各基团的定义如说明书中所述。所述的式I化合物具有抑制微管蛋白活性的效果,可以用于制备治疗或预防与微管蛋白调节异常相关的哺乳动物疾病的药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)