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1. (WO2017181972) USE OF ISOTHIOCYANATE COMPOUNDS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/181972 International Application No.: PCT/CN2017/081292
Publication Date: 26.10.2017 International Filing Date: 20.04.2017
IPC:
A61K 31/26 (2006.01) ,A61K 45/00 (2006.01) ,A61K 31/655 (2006.01) ,A61K 31/5375 (2006.01) ,A61K 31/277 (2006.01) ,A61K 31/695 (2006.01) ,A61K 45/06 (2006.01) ,A61P 3/06 (2006.01) ,A61P 1/16 (2006.01)
Applicants: JC (WUXI) COMPANY, INC.[CN/CN]; No.200, Floor 2, 5 District, Building A, Science and Technology Park, 7 Changjiang Road, Xinwu District Wuxi, Jiangsu 214028, CN
Inventors: CHENG, Jingcai; CN
ZHANG, Chunxia; CN
CHENG, Zhiwei; CN
Agent: XU & PARTNERS, LLC.; Room No.106, Building No.1, Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201610257997.822.04.2016CN
201610258064.022.04.2016CN
Title (EN) USE OF ISOTHIOCYANATE COMPOUNDS
(FR) UTILISATION DE COMPOSÉS D'ISOTHIOCYANATE
(ZH) 异硫氰酸酯类化合物的应用
Abstract: front page image
(EN) Disclosed is the use of isothiocyanate compounds. In particular, disclosed is the use of a compound as shown by formula (I) or a derivative as shown by formula (II) in the manufacture of a composition or preparation for preventing and/or treating hyperlipidemia. The compound of the present invention can reduce the levels of triglycerides and low density lipoproteins in the serum of mammals (such as rats and humans), increase the level of high density lipoproteins in the serum, and reduce the level of total bilirubin in the serum of mammals (such as rats and humans).
(FR) La présente invention concerne l'utilisation de composés d’isothiocyanate. En particulier, l'invention concerne l'utilisation d'un composé tel que représenté par la formule (I) ou un dérivé tel que représenté par la formule (II) dans la fabrication d'une composition ou préparation pour prévenir et/ou traiter l'hyperlipidémie. Le composé de la présente invention peut réduire les taux de triglycérides et de lipoprotéines de basse densité dans le sérum de mammifères (tels que des rats et des humains), augmenter le taux de lipoprotéines de haute densité dans le sérum, et réduire le taux de bilirubine totale dans le sérum de mammifères (tels que des rats et des humains).
(ZH) 本发明公开了异硫氰酸酯类化合物的应用,具体地,本发明公开了一种式(I)所示的化合物或式(II)所示衍生物的用途,用于制备组合物或制剂,预防和/或治疗高血脂症。本发明化合物可降低哺乳动物(如大鼠、人)血清中甘油三酯和低密度脂蛋白水平,提高血清中高密度脂蛋白的水平,降低哺乳动物(如大鼠、人)血清中总胆红素水平。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)