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1. (WO2017181943) PHARMACEUTICAL COMPOSITION CONTAINING PEITC AND USE THEREOF IN CANCER TREATMENT

Pub. No.:    WO/2017/181943    International Application No.:    PCT/CN2017/080960
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Wed Apr 19 01:59:59 CEST 2017
IPC: A61K 31/26
A61P 35/00
G01N 33/68
G01N 33/574
Applicants: JC (WUXI) COMPANY, INC.
无锡杰西医药股份有限公司
Inventors: CHUNG, Fung-Lung
宗方隆
CHENG, Jingcai
程景才
AGGARWAL, Monika
阿加沃尔M
Title: PHARMACEUTICAL COMPOSITION CONTAINING PEITC AND USE THEREOF IN CANCER TREATMENT
Abstract:
Provided in the present invention is a use of PEITC for preparing a preparation or composition. The preparation or composition is used for: (a) altering the mutant p53 to restore the wild-type activity; (b) inhibiting the tumour cell proliferation caused by the mutant p53; (c) inducing apoptosis of mutant p53 tumour cells; and/or (d) preventing or treating diseases based on p53 mutations. Also provided in the present invention are a use of a p53 gene detection reagent, a kit comprising PEITC and the p53 gene detection reagent, and a method for non-therapeutically inhibiting tumour cells in vitro.