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1. (WO2017181920) METHOD FOR PREPARING RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR

Pub. No.:    WO/2017/181920    International Application No.:    PCT/CN2017/080737
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Tue Apr 18 01:59:59 CEST 2017
IPC: C12N 15/70
C12N 15/27
C12N 1/21
C07K 1/107
C12R 1/19
Applicants: JIANGSU HENGRUI MEDICINE CO., LTD.
江苏恒瑞医药股份有限公司
Inventors: YU, Kui
喻馗
WANG, Hongwei
王宏伟
TIAN, Jing
田静
ZENG, Xiang
曾翔
KONG, Xianglin
孔祥林
Title: METHOD FOR PREPARING RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR
Abstract:
Provided is a method for preparing recombinant human granulocyte colony-stimulating factor; the cDNA used is obtained on the basis of a human source sequence modifed according to Escherichia coli codon preference, and has a high level of expression in Escherichia coli engineered bacteria.