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1. (WO2017181849) INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION

Pub. No.:    WO/2017/181849    International Application No.:    PCT/CN2017/079585
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Fri Apr 07 01:59:59 CEST 2017
IPC: C07D 271/08
A61K 31/4245
A61K 31/5377
A61P 35/00
A61P 25/24
A61P 25/28
A61P 17/02
A61P 27/12
A61P 37/06
Applicants: JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.
江苏豪森药业集团有限公司
SHANGHAI HANSOH BIOMEDICAL CO., LTD.
上海翰森生物医药科技有限公司
Inventors: WU, Shenghua
吴盛华
LI, Kailong
李凯龙
BAO, Rudi
包如迪
Title: INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION
Abstract:
The present invention relates to an indoleamine 2,3-dioxygenase inhibitor having the structure of formula (I), a preparation method therefor, and an application. The IDO inhibitor is an N'-hydroxyl-N-phenylformamidine derivative, has high inhibitory activity on IDO, effectively inhibits IDO activity, and may also be used to inhibit patient immunosuppression. The inhibitor may be widely applied to treat or prevent cancers or tumours, viral infections, depression, neurodegenerative diseases, trauma, age-related cataracts, organ transplant rejection or autoimmune diseases, and has the potential to be developed into a new generation of immunosuppressors.