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1. (WO2017181437) NON-AMINO ACID METHOD FOR CHEMICAL TOTAL SYNTHESIS OF POLYPEPTIDES

Pub. No.:    WO/2017/181437    International Application No.:    PCT/CN2016/080572
Publication Date: Fri Oct 27 01:59:59 CEST 2017 International Filing Date: Fri Apr 29 01:59:59 CEST 2016
IPC: C07K 1/06
C07K 1/04
C07K 5/107
C07K 7/66
Applicants: CHEN, Ming
陈铭
Inventors: CHEN, Ming
陈铭
Title: NON-AMINO ACID METHOD FOR CHEMICAL TOTAL SYNTHESIS OF POLYPEPTIDES
Abstract:
Provided is a non-amino acid method for chemical total synthesis of polypeptides. Said non-amino acid method for chemical total synthesis of polypeptides uses as a raw material ketoamide compounds, which are synthesized into a polypeptide by means of reductive amination under acetal protection. The present non-amino acid method for chemical synthesis of polypeptides has the advantages of high synthesis efficiency, low cost, broad applicability, few side reactions, and ease of popularization.