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1. (WO2017181128) INTRATUMORAL ADMINISTRATION OF PARTICLES CONTAINING A TOLL-LIKE RECEPTOR 9 AGONIST AND A TUMOR ANTIGEN FOR TREATING CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/181128    International Application No.:    PCT/US2017/027788
Publication Date: 19.10.2017 International Filing Date: 14.04.2017
IPC:
A61K 39/00 (2006.01), A61K 39/39 (2006.01), A61K 47/02 (2006.01), A61K 47/10 (2017.01), A61K 47/36 (2006.01), A61K 31/711 (2006.01), A61P 35/00 (2006.01)
Applicants: DYNAVAX TECHNOLOGIES CORPORATION [US/US]; 2929 Seventh Street, Suite 100 Berkeley, CA 94710 (US)
Inventors: GUIDUCCI, Cristiana; (US).
NAIK, Edwina; (US).
MILLEY, Robert, J.; (US).
CHIPMAN, Stewart, D.; (US)
Agent: LEKUTIS, Christine; (US).
BANKO, Max; (US).
AHN, Sejin; (US).
ARJOMAND, Mehran; (US).
AIKEN, Charity; (US)
Priority Data:
62/323,622 15.04.2016 US
62/439,438 27.12.2016 US
Title (EN) INTRATUMORAL ADMINISTRATION OF PARTICLES CONTAINING A TOLL-LIKE RECEPTOR 9 AGONIST AND A TUMOR ANTIGEN FOR TREATING CANCER
(FR) ADMINISTRATION INTRATUMORALE DE PARTICULES CONTENANT UN AGONISTE DU RÉCEPTEUR TOLL 9 ET UN ANTIGÈNE TUMORAL POUR LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)The present disclosure relates to methods for treating cancer by intratumoral delivery of particles containing a Toll-like receptor 9 agonist (TLR9) and a tumor antigen, in which the TLR9 agonist is a polynucleotide or a chimeric compound thereof. The methods of the present disclosure involve injection of the particles into at least one tumor, and are effective for treating both injected and uninjected tumors of a mammalian subject. Additionally, the present disclosure provides immunogenic compositions containing the particles, as well as methods of manufacture thereof.
(FR)La présente invention concerne des méthodes de traitement du cancer par administration intratumorale de particules contenant un agoniste du récepteur Toll 9 (TLR9) et un antigène tumoral, l'agoniste de TLR9 étant un polynucléotide ou un composé chimérique de celui-ci. Les méthodes de la présente invention consistent à injecter des particules dans au moins une tumeur, et sont efficaces pour le traitement à la fois de tumeurs injectées et non injectées d'un sujet mammalien. De plus, la présente invention concerne des compositions immunogènes contenant les particules, ainsi que leurs procédés de fabrication.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)