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1. (WO2017181105) METHODS AND COMPOSITIONS FOR TREATING METABOLIC IMBALANCE

Pub. No.:    WO/2017/181105    International Application No.:    PCT/US2017/027759
Publication Date: Fri Oct 20 01:59:59 CEST 2017 International Filing Date: Sat Apr 15 01:59:59 CEST 2017
IPC: C12N 15/86
G01N 33/574
A61K 35/30
Applicants: UNIVERSITY OF MASSACHUSETTS
Inventors: GAO, Guangping
GESSLER, Dominic
Title: METHODS AND COMPOSITIONS FOR TREATING METABOLIC IMBALANCE
Abstract:
In some aspects, the disclosure relates to compositions and methods useful for the diagnosis and treatment of diseases associated with a metabolic imbalance in a subject (e.g.,cancer). In some embodiments, the methods comprise administering to a subject an N-acetylaspartate (NAA)-depleting agent or an N-acetylaspartate (NAA)-increasing agent based upon the subject's metabolic profile.