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Pub. No.:    WO/2017/181049    International Application No.:    PCT/US2017/027685
Publication Date: 19.10.2017 International Filing Date: 14.04.2017
G01N 33/53 (2006.01), A61P 35/00 (2006.01), A61K 39/395 (2006.01)
Applicants: CHARLESTONPHARMA, LLC [US/US]; 645 Meeting Street, Suite 4 Charleston, South Carolina 29403 (US)
Inventors: FERNANDES, Daniel; (US).
Agent: LIU, Shan; (US).
LIETO, Louis D.; (US).
ARONIN, Caren P.; (US).
ANDRES, JR., Charles; (US).
VAN GOOR, David; (US).
MATA, David; (US).
ROWE, Derrick; (US).
TIAN, Feng; (US).
XIN, Xiaoban; (US).
RHO, Byunghwi; (US).
GIRINATH, Prashant; (US).
MCANDREW, Christopher W.; (US).
HERDER, Rachel; (US).
AGRAWAL, Trisha; (US).
UJWAL, Rachna; (US).
DASGUPTA, Indrani; (US).
KENESKY, Craig; (US)
Priority Data:
62/323,294 15.04.2016 US
62/414,357 28.10.2016 US
Abstract: front page image
(EN)The invention is directed to a method of treating cancers, predicting the efficacy of treatment of cancers, assessing the probability of resistance developing to treatment of cancer by measuring the level of cytoplasmic nucleolin or the ratio of cytoplasmic to surface expression of nucleolin protein.
(FR)L'invention concerne une méthode destinée à traiter les cancers, à prédire l'efficacité du traitement des cancers, à évaluer la probabilité de développer une résistance au traitement du cancer par mesure du taux de nucléoline cytoplasmique ou du rapport de l'expression cytoplasmique à superficielle de la protéine de nucléoline.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)